Publication: MICROBUBBLES: THE NEW DELIVERY VESICLES
Loading...
Date
2024-04-18
Authors
Journal Title
Journal ISSN
Volume Title
Type
Abstract
Abstract
Microbubbles are bubbles that are composed of an outer shell and an inner core. They are called micro because they can get as small as a red blood cell, <10μm. The core is usually a perfluorocarbon gas, or a thick oil like PEG-40S. The shell is typically a protein or lipid monolayer, allowing for it to be broken down by the body without serious side effects. Microbubbles have been used as contrast agents in ultrasound imaging, but recently came under topic of discussion for other biomedical applications because of their size and composition. The microbubbles in this research project are composed of a thick oil core with a lipid monolayer shell.
Microbubbles are currently used as abstract agents for ultrasonic imaging. However, recent studies show they might be used for other things like gene therapy or drug delivery. Through research it is found that microbubbles can have drugs linked onto a lipid shell, either negatively charged drugs linked onto them positive head of the lipid, or drugs can link to the hydrophobic tail of the microbubble. If the drug is not linked to the lipid shell, it is encapsulated in the gas/oil core of the microbubble as it is made. To further reduce side effects of drug delivery, targeting ligands can be added onto the bubble shell in the same linking process as the drugs, to make sure the bubbles are delivered to the correct area.
With all the information about microbubbles: size, composition, lack of immune system response etc; leads to the question: what else can it do? Since it is the size of a red blood cell it means it should pass through the blood brain barrier, leading to the potential use for brain diseases.